This demo uses imperative chart updates. The generated code is a faithful Angular translation: open it in CodeSandbox to run and tweak.

import { Component, AfterViewInit, OnDestroy, ViewChild } from '@angular/core';
import {
  ChartComponent,
  ApexAxisChartSeries,
  ApexNonAxisChartSeries,
  ApexChart,
  ApexXAxis,
  ApexYAxis,
  ApexTitleSubtitle,
  ApexDataLabels,
  ApexStroke,
  ApexFill,
  ApexLegend,
  ApexTooltip,
  ApexMarkers,
  ApexPlotOptions,
  ApexResponsive,
  ApexGrid,
  ApexAnnotations,
  ApexStates,
  ApexTheme,
  NgApexchartsModule,
} from 'ng-apexcharts';

export type ChartOptions = {
  series?: ApexAxisChartSeries | ApexNonAxisChartSeries;
  chart?: ApexChart;
  xaxis?: ApexXAxis;
  yaxis?: ApexYAxis | ApexYAxis[];
  title?: ApexTitleSubtitle;
  subtitle?: ApexTitleSubtitle;
  dataLabels?: ApexDataLabels;
  stroke?: ApexStroke;
  fill?: ApexFill;
  legend?: ApexLegend;
  tooltip?: ApexTooltip;
  markers?: ApexMarkers;
  plotOptions?: ApexPlotOptions;
  responsive?: ApexResponsive[];
  grid?: ApexGrid;
  annotations?: ApexAnnotations;
  states?: ApexStates;
  theme?: ApexTheme;
  colors?: string[];
  labels?: any;
};

@Component({
  selector: 'app-chart',
  standalone: true,
  imports: [NgApexchartsModule],
  templateUrl: './chart.component.html',
})
export class AppChart implements AfterViewInit, OnDestroy {
  @ViewChild('chart') chart!: ChartComponent;
  private regions: any = ['North America', 'Europe', 'Asia Pacific', 'Latin America'];

  private quarters: any = ['Q1', 'Q2', 'Q3', 'Q4'];

  private monthsByQuarter: any = [
          ['Jan', 'Feb', 'Mar'],
          ['Apr', 'May', 'Jun'],
          ['Jul', 'Aug', 'Sep'],
          ['Oct', 'Nov', 'Dec'],
        ];

  private weeks: any = ['Wk 1', 'Wk 2', 'Wk 3', 'Wk 4'];

  private pseudo = (seed: any, lo: any, hi: any): any => {
          var x = Math.sin(seed) * 10000
          x = x - Math.floor(x)
          return Math.round(lo + x * (hi - lo))
        };

  private clamp = (v: any, lo: any, hi: any): any => {
          return Math.max(lo, Math.min(hi, v))
        };

  private heatPlot: any = {
          heatmap: {
            radius: 2,
            shadeIntensity: 0.5,
            colorScale: {
              ranges: [
                { from: 0, to: 30, color: '#C8E6C9', name: 'Low' },
                { from: 31, to: 60, color: '#66BB6A', name: 'Medium' },
                { from: 61, to: 80, color: '#FB8C00', name: 'High' },
                { from: 81, to: 100, color: '#E53935', name: 'Peak' },
              ],
            },
          },
        };

  private rootValues: any = this.regions.map(function (region, ri) {
          return this.quarters.map(function (q, qi) {
            return this.pseudo(ri * 31 + qi * 7 + 3, 20, 95)
          })
        });

  private heatRootSeries: any = this.regions.map(function (region, ri) {
          return {
            name: region,
            data: this.quarters.map(function (q, qi) {
              return { x: q, y: this.rootValues[ri][qi], drilldown: 'r' + ri + '-q' + qi }
            }),
          }
        });

  private heatChildren: any = [];

  public chartOptions: Partial<ChartOptions> = {
          series: this.heatRootSeries,
          chart: {
            type: 'heatmap',
            height: 450,
            toolbar: {
              show: false,
            },
          },
          dataLabels: {
            enabled: true,
          },
          plotOptions: this.heatPlot,
          title: {
            text: 'Sales Intensity by Region and Quarter',
            align: 'left',
          },
          subtitle: {
            text: 'Click any cell to drill into its weekly breakdown (pointer cursor marks drillable cells). Use the breadcrumb to go back.',
            align: 'left',
          },
          drilldown: {
            enabled: true,
            breadcrumb: {
              show: true,
              position: 'top-right',
              rootLabel: 'All Regions',
              separator: ' / ',
            },
            series: this.heatChildren,
          },
        };
  ngAfterViewInit() {
    (window as any).ApexCharts.setLicense('APEX-eyJpc3N1ZURhdGUiOiIyMDI2LTA0LTE2IiwiZXhwaXJ5RGF0ZSI6IjIwNTItMDQtMTciLCJwbGFuIjoiZW50ZXJwcmlzZSIsImRvbWFpbnMiOlsiYXBleGNoYXJ0cy5jb20iLCIxMjcuMC4wLjEiXX0=');
    this.regions.forEach(function (region, ri) {
            this.quarters.forEach(function (q, qi) {
              var base = this.rootValues[ri][qi]
              var months = this.monthsByQuarter[qi]

              // Draw a raw +/-15 wobble for each of the 12 weekly cells, then re-center
              // the wobbles so they sum to zero. The weekly cells therefore average back
              // to the region+quarter score: the drilldown preserves the headline instead
              // of inventing a new total, while individual weeks still vary realistically.
              var raw = []
              months.forEach(function (m, mi) {
                this.weeks.forEach(function (wk, wi) {
                  raw.push(this.pseudo(ri * 101 + qi * 53 + mi * 17 + wi * 3 + 11, -15, 15))
                })
              })
              var mean =
                raw.reduce(function (a, b) {
                  return a + b
                }, 0) / raw.length
              var k = 0

              this.heatChildren.push({
                id: 'r' + ri + '-q' + qi,
                name: region + ' / ' + q,
                series: months.map(function (m, mi) {
                  return {
                    name: m,
                    data: this.weeks.map(function (wk, wi) {
                      var y = this.clamp(Math.round(base + raw[k] - mean), 0, 100)
                      k++
                      return { x: wk, y: y }
                    }),
                  }
                }),
              })
            })
          })
  }

  ngOnDestroy() {
    // no cleanup needed
  }
}
Heatmap with Drilldown - Angular Heatmap Charts | ApexCharts.js | ApexCharts.js