This demo uses imperative chart updates. The generated code is a faithful Angular translation: open it in CodeSandbox to run and tweak.

import { Component, AfterViewInit, OnDestroy, ViewChild } from '@angular/core';
import {
  ChartComponent,
  ApexAxisChartSeries,
  ApexNonAxisChartSeries,
  ApexChart,
  ApexXAxis,
  ApexYAxis,
  ApexTitleSubtitle,
  ApexDataLabels,
  ApexStroke,
  ApexFill,
  ApexLegend,
  ApexTooltip,
  ApexMarkers,
  ApexPlotOptions,
  ApexResponsive,
  ApexGrid,
  ApexAnnotations,
  ApexStates,
  ApexTheme,
  NgApexchartsModule,
} from 'ng-apexcharts';

export type ChartOptions = {
  series?: ApexAxisChartSeries | ApexNonAxisChartSeries;
  chart?: ApexChart;
  xaxis?: ApexXAxis;
  yaxis?: ApexYAxis | ApexYAxis[];
  title?: ApexTitleSubtitle;
  subtitle?: ApexTitleSubtitle;
  dataLabels?: ApexDataLabels;
  stroke?: ApexStroke;
  fill?: ApexFill;
  legend?: ApexLegend;
  tooltip?: ApexTooltip;
  markers?: ApexMarkers;
  plotOptions?: ApexPlotOptions;
  responsive?: ApexResponsive[];
  grid?: ApexGrid;
  annotations?: ApexAnnotations;
  states?: ApexStates;
  theme?: ApexTheme;
  colors?: string[];
  labels?: any;
};

@Component({
  selector: 'app-chart',
  standalone: true,
  imports: [NgApexchartsModule],
  templateUrl: './chart.component.html',
})
export class AppChart implements AfterViewInit, OnDestroy {
  @ViewChild('chart') chart!: ChartComponent;
  private signal = (): any => {
          var out = []
          for (var i = 0; i < 40; i++) {
            var v = 50 + 22 * Math.sin(i / 4.0) + 9 * Math.sin(i / 1.4) + i * 0.4
            out.push([i, Math.round(v)])
          }
          return out
        };

  private readout: any = document.getElementById('ink-readout');

  public chartOptions: Partial<ChartOptions> = {
          series: [{ name: 'Signal', data: this.signal() }],
          chart: {
            id: 'signal',
            type: 'line',
            height: 380,
            fontFamily: 'Helvetica, Arial, sans-serif',
            animations: { enabled: false },
            ink: { enabled: true, palette: true },
            history: { enabled: true },
            toolbar: { show: false },
            zoom: { enabled: false },
          },
          stroke: { width: 2, curve: 'smooth' },
          colors: ['#0EA5E9'],
          title: { text: 'Signal (drag the callouts)', align: 'left' },
          xaxis: { type: 'numeric', title: { text: 'Sample' } },
          yaxis: { title: { text: 'Value' } },
          annotations: {
            points: [
              {
                x: 6,
                y: 74,
                id: 'peak',
                marker: {
                  size: 7,
                  fillColor: '#fff',
                  strokeColor: '#0EA5E9',
                  strokeWidth: 3,
                },
                label: {
                  text: 'Peak',
                  borderColor: '#0EA5E9',
                  style: { color: '#fff', background: '#0EA5E9' },
                },
              },
              {
                x: 20,
                y: 52,
                id: 'dip',
                marker: {
                  size: 7,
                  fillColor: '#fff',
                  strokeColor: '#ef4444',
                  strokeWidth: 3,
                },
                label: {
                  text: 'Watch',
                  borderColor: '#ef4444',
                  style: { color: '#fff', background: '#ef4444' },
                },
              },
            ],
            xaxis: [
              {
                x: 10,
                x2: 16,
                id: 'window',
                fillColor: '#7DD3FC',
                opacity: 0.28,
                label: {
                  text: 'Window',
                  style: { color: '#fff', background: '#0EA5E9' },
                },
              },
            ],
            yaxis: [
              {
                y: 62,
                id: 'target',
                borderColor: '#f59e0b',
                strokeDashArray: 4,
                label: {
                  text: 'Target',
                  style: { color: '#fff', background: '#f59e0b' },
                },
              },
            ],
          },
        };
  ngAfterViewInit() {
    (window as any).ApexCharts.setLicense('APEX-eyJleHBpcnlEYXRlIjoiMjEyNi0wNy0wNCIsImlzc3VlRGF0ZSI6IjIwMjYtMDctMjgiLCJwbGFuIjoicHJlbWl1bSIsImRvbWFpbnMiOlsiYXBleGNoYXJ0cy5jb20iLCIxMjcuMC4wLjEiLCJsb2NhbGhvc3QiXSwic2lnIjoieVBmb1VCc0Z3TU9ZdUEyaEZkR0I2Y1FtZ0JITUtXcVdJSjB2NVRESXRZbFR3eDJMUmh6R2x0RUc3VXJ4X0s3b25ZMWRZb2Z2VGItN01ydFYyNDVyOWcifQ==');

    this.chart.addEventListener('annotationDragged', (c, o) => {
            this.readout.textContent =
              "Moved '" +
              o.id +
              "' to x=" +
              Number(o.x).toFixed(2) +
              ', y=' +
              Number(o.y).toFixed(2)
          })
    this.chart.addEventListener('annotationStyled', (c, o) => {
            this.readout.textContent = "Restyled '" + o.id + "'"
          })
    this.chart.addEventListener('annotationDeleted', (c, o) => {
            this.readout.textContent = "Deleted '" + o.id + "' (Ctrl/Cmd+Z restores it)"
          })
  }

  ngOnDestroy() {
    // no cleanup needed
  }
}
Annotation Authoring (Ink) - Angular Interactivity | ApexCharts.js | ApexCharts.js