This demo uses imperative chart updates. The generated code is a faithful Angular translation: open it in CodeSandbox to run and tweak.

import { Component, AfterViewInit, OnDestroy, ViewChild } from '@angular/core';
import {
  ChartComponent,
  ApexAxisChartSeries,
  ApexNonAxisChartSeries,
  ApexChart,
  ApexXAxis,
  ApexYAxis,
  ApexTitleSubtitle,
  ApexDataLabels,
  ApexStroke,
  ApexFill,
  ApexLegend,
  ApexTooltip,
  ApexMarkers,
  ApexPlotOptions,
  ApexResponsive,
  ApexGrid,
  ApexAnnotations,
  ApexStates,
  ApexTheme,
  NgApexchartsModule,
} from 'ng-apexcharts';

export type ChartOptions = {
  series?: ApexAxisChartSeries | ApexNonAxisChartSeries;
  chart?: ApexChart;
  xaxis?: ApexXAxis;
  yaxis?: ApexYAxis | ApexYAxis[];
  title?: ApexTitleSubtitle;
  subtitle?: ApexTitleSubtitle;
  dataLabels?: ApexDataLabels;
  stroke?: ApexStroke;
  fill?: ApexFill;
  legend?: ApexLegend;
  tooltip?: ApexTooltip;
  markers?: ApexMarkers;
  plotOptions?: ApexPlotOptions;
  responsive?: ApexResponsive[];
  grid?: ApexGrid;
  annotations?: ApexAnnotations;
  states?: ApexStates;
  theme?: ApexTheme;
  colors?: string[];
  labels?: any;
};

@Component({
  selector: 'app-chart',
  standalone: true,
  imports: [NgApexchartsModule],
  templateUrl: './chart.component.html',
})
export class AppChart implements AfterViewInit, OnDestroy {
  @ViewChild('chart') chart!: ChartComponent;
  public chartOptions: Partial<ChartOptions> = {
          series: [
            {
              name: 'Revenue',
              type: 'column',
              data: [140, 200, 250, 150, 250, 280, 380, 460],
            },
            {
              name: 'Headcount',
              type: 'column',
              data: [110, 300, 310, 400, 410, 490, 650, 850],
            },
            {
              name: 'Share Price',
              type: 'line',
              data: [20, 29, 37, 36, 44, 45, 50, 58],
            },
          ],
          chart: {
            height: 350,
            type: 'line',
            stacked: false,
          },
          dataLabels: {
            enabled: false,
          },
          stroke: {
            width: [1, 1, 4],
          },
          title: {
            text: 'Company Performance (2017 - 2024)',
            align: 'left',
            offsetX: 110,
          },
          xaxis: {
            categories: [2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024],
          },
          yaxis: [
            {
              seriesName: 'Revenue',
              axisTicks: {
                show: true,
              },
              axisBorder: {
                show: true,
                color: '#008FFB',
              },
              labels: {
                style: {
                  colors: '#008FFB',
                },
              },
              title: {
                text: 'Revenue ($M)',
                style: {
                  color: '#008FFB',
                },
              },
              tooltip: {
                enabled: true,
              },
            },
            {
              seriesName: 'Headcount',
              opposite: true,
              axisTicks: {
                show: true,
              },
              axisBorder: {
                show: true,
                color: '#00E396',
              },
              labels: {
                style: {
                  colors: '#00E396',
                },
              },
              title: {
                text: 'Headcount',
                style: {
                  color: '#00E396',
                },
              },
            },
            {
              seriesName: 'Share Price',
              opposite: true,
              axisTicks: {
                show: true,
              },
              axisBorder: {
                show: true,
                color: '#FEB019',
              },
              labels: {
                style: {
                  colors: '#FEB019',
                },
              },
              title: {
                text: 'Share Price ($)',
                style: {
                  color: '#FEB019',
                },
              },
            },
          ],
          tooltip: {
            fixed: {
              enabled: true,
              position: 'topLeft', // topRight, topLeft, bottomRight, bottomLeft
              offsetY: 30,
              offsetX: 60,
            },
          },
          legend: {
            horizontalAlign: 'left',
            offsetX: 40,
          },
        };
  ngAfterViewInit() {
    (window as any).ApexCharts.setLicense('APEX-eyJpc3N1ZURhdGUiOiIyMDI2LTA0LTE2IiwiZXhwaXJ5RGF0ZSI6IjIwNTItMDQtMTciLCJwbGFuIjoiZW50ZXJwcmlzZSIsImRvbWFpbnMiOlsiYXBleGNoYXJ0cy5jb20iLCIxMjcuMC4wLjEiXX0=');
  }

  ngOnDestroy() {
    // no cleanup needed
  }
}
Multiple Y-Axis - Angular Mixed / Combo Charts | ApexCharts.js | ApexCharts.js