This demo uses imperative chart updates. The generated code is a faithful Angular translation: open it in CodeSandbox to run and tweak.

import { Component, AfterViewInit, OnDestroy, ViewChild } from '@angular/core';
import {
  ChartComponent,
  ApexAxisChartSeries,
  ApexNonAxisChartSeries,
  ApexChart,
  ApexXAxis,
  ApexYAxis,
  ApexTitleSubtitle,
  ApexDataLabels,
  ApexStroke,
  ApexFill,
  ApexLegend,
  ApexTooltip,
  ApexMarkers,
  ApexPlotOptions,
  ApexResponsive,
  ApexGrid,
  ApexAnnotations,
  ApexStates,
  ApexTheme,
  NgApexchartsModule,
} from 'ng-apexcharts';

export type ChartOptions = {
  series?: ApexAxisChartSeries | ApexNonAxisChartSeries;
  chart?: ApexChart;
  xaxis?: ApexXAxis;
  yaxis?: ApexYAxis | ApexYAxis[];
  title?: ApexTitleSubtitle;
  subtitle?: ApexTitleSubtitle;
  dataLabels?: ApexDataLabels;
  stroke?: ApexStroke;
  fill?: ApexFill;
  legend?: ApexLegend;
  tooltip?: ApexTooltip;
  markers?: ApexMarkers;
  plotOptions?: ApexPlotOptions;
  responsive?: ApexResponsive[];
  grid?: ApexGrid;
  annotations?: ApexAnnotations;
  states?: ApexStates;
  theme?: ApexTheme;
  colors?: string[];
  labels?: any;
};

@Component({
  selector: 'app-chart',
  standalone: true,
  imports: [NgApexchartsModule],
  templateUrl: './chart.component.html',
})
export class AppChart implements AfterViewInit, OnDestroy {
  @ViewChild('chart') chart!: ChartComponent;
  public chartOptions: Partial<ChartOptions> = {
          series: [
            {
              name: 'Profit',
              type: 'column',
              data: [5, 12, -8, 14, -3, 9, -2, 6],
            },
            {
              name: 'Units Sold',
              type: 'column',
              data: [1.2, 2.1, 1.8, 2.7, 2.0, 2.4, 1.9, 2.6],
            },
            {
              name: 'Index',
              type: 'line',
              data: [25, 27, 26, 29, 28, 29, 30, 30],
            },
          ],
          chart: {
            height: 350,
            type: 'line',
            stacked: false,
          },
          stroke: {
            width: [0, 0, 4],
          },
          title: {
            text: 'Multiple Y-Axes With Aligned Zero',
            align: 'left',
          },
          xaxis: {
            categories: ['Q1', 'Q2', 'Q3', 'Q4', 'Q5', 'Q6', 'Q7', 'Q8'],
          },
          yaxis: [
            {
              seriesName: 'Profit',
              alignZero: true,
              axisTicks: { show: true },
              axisBorder: { show: true, color: '#008FFB' },
              labels: { style: { colors: '#008FFB' } },
              title: { text: 'Profit (mixed +/-)', style: { color: '#008FFB' } },
            },
            {
              seriesName: 'Units Sold',
              alignZero: true,
              opposite: true,
              axisTicks: { show: true },
              axisBorder: { show: true, color: '#00E396' },
              labels: { style: { colors: '#00E396' } },
              title: { text: 'Units (positive only)', style: { color: '#00E396' } },
            },
            {
              seriesName: 'Index',
              alignZero: true,
              opposite: true,
              axisTicks: { show: true },
              axisBorder: { show: true, color: '#FEB019' },
              labels: { style: { colors: '#FEB019' } },
              title: { text: 'Index', style: { color: '#FEB019' } },
            },
          ],
          tooltip: { shared: true, intersect: false },
          legend: { horizontalAlign: 'left' },
        };
  ngAfterViewInit() {
    (window as any).ApexCharts.setLicense('APEX-eyJpc3N1ZURhdGUiOiIyMDI2LTA0LTE2IiwiZXhwaXJ5RGF0ZSI6IjIwNTItMDQtMTciLCJwbGFuIjoiZW50ZXJwcmlzZSIsImRvbWFpbnMiOlsiYXBleGNoYXJ0cy5jb20iLCIxMjcuMC4wLjEiXX0=');
  }

  ngOnDestroy() {
    // no cleanup needed
  }
}
Multiple Y-Axes (Aligned Zero) - Angular Mixed / Combo Charts | ApexCharts.js | ApexCharts.js