This demo uses imperative chart updates. The generated code is a faithful Angular translation: open it in CodeSandbox to run and tweak.

import { Component, AfterViewInit, OnDestroy, ViewChild } from '@angular/core';
import {
  ChartComponent,
  ApexAxisChartSeries,
  ApexNonAxisChartSeries,
  ApexChart,
  ApexXAxis,
  ApexYAxis,
  ApexTitleSubtitle,
  ApexDataLabels,
  ApexStroke,
  ApexFill,
  ApexLegend,
  ApexTooltip,
  ApexMarkers,
  ApexPlotOptions,
  ApexResponsive,
  ApexGrid,
  ApexAnnotations,
  ApexStates,
  ApexTheme,
  NgApexchartsModule,
} from 'ng-apexcharts';

export type ChartOptions = {
  series?: ApexAxisChartSeries | ApexNonAxisChartSeries;
  chart?: ApexChart;
  xaxis?: ApexXAxis;
  yaxis?: ApexYAxis | ApexYAxis[];
  title?: ApexTitleSubtitle;
  subtitle?: ApexTitleSubtitle;
  dataLabels?: ApexDataLabels;
  stroke?: ApexStroke;
  fill?: ApexFill;
  legend?: ApexLegend;
  tooltip?: ApexTooltip;
  markers?: ApexMarkers;
  plotOptions?: ApexPlotOptions;
  responsive?: ApexResponsive[];
  grid?: ApexGrid;
  annotations?: ApexAnnotations;
  states?: ApexStates;
  theme?: ApexTheme;
  colors?: string[];
  labels?: any;
};

@Component({
  selector: 'app-chart',
  standalone: true,
  imports: [NgApexchartsModule],
  templateUrl: './chart.component.html',
})
export class AppChart implements AfterViewInit, OnDestroy {
  @ViewChild('chart') chart!: ChartComponent;
  private mulberry32 = (seed: any): any => {
        return function () {
          seed |= 0
          seed = (seed + 0x6d2b79f5) | 0
          var t = Math.imul(seed ^ (seed >>> 15), 1 | seed)
          t = (t + Math.imul(t ^ (t >>> 7), 61 | t)) ^ t
          return ((t ^ (t >>> 14)) >>> 0) / 4294967296
        }
      };

  private T0: any = new Date('01 Jan 2025').getTime();

  private heartRate = (seed: any, base: any, tachyFrom: any): any => {
        var rand = this.mulberry32(seed)
        var out = []
        var ts = this.T0
        var val = base
        for (var i = 0; i < 48; i++) {
          val += (rand() - 0.5) * 6
          var v = val
          // P-07 trends tachycardic until the 30h medication event pulls it back.
          if (tachyFrom && i >= tachyFrom && i < 30) v = val + 28
          if (tachyFrom && i >= 30) v = val + Math.max(0, 28 - (i - 30) * 3)
          out.push([ts, Math.round(v)])
          ts += 3600000 // hourly
        }
        return out
      };

  private patientSeries: any = [];

  public chartOptions: Partial<ChartOptions> = {
          series: this.patientSeries,
          chart: {
            id: 'vitalsTrellis',
            type: 'line',
            animations: {
              enabled: false,
            },
          },
          trellis: {
            by: 'patient',
            minPanelWidth: 240,
            panelHeight: 130,
            gap: 12,
            tooltip: 'grid',
          },
          colors: ['#0F766E'],
          stroke: {
            width: 2,
            curve: 'straight',
          },
          annotations: {
            yaxis: [
              {
                y: 60,
                y2: 100,
                fillColor: '#22C55E',
                opacity: 0.1,
              },
            ],
            xaxis: [
              {
                x: new Date('01 Jan 2025').getTime() + 30 * 3600000,
                scope: 'P-07',
                borderColor: '#D97706',
                strokeDashArray: 4,
                label: {
                  text: 'medication',
                  orientation: 'horizontal',
                  style: {
                    color: '#92400E',
                    background: '#FEF3C7',
                    fontSize: '10px',
                  },
                },
              },
            ],
          },
          xaxis: {
            type: 'datetime',
          },
          yaxis: {
            labels: {
              formatter: (val) => {
                return Math.round(val) + ' bpm'
              },
            },
          },
          dataLabels: {
            enabled: false,
          },
          tooltip: {
            x: {
              format: 'dd MMM HH:mm',
            },
          },
        };
  ngAfterViewInit() {
    (window as any).ApexCharts.setLicense('APEX-eyJleHBpcnlEYXRlIjoiMjEyNi0wNy0wNCIsImlzc3VlRGF0ZSI6IjIwMjYtMDctMjgiLCJwbGFuIjoicHJlbWl1bSIsImRvbWFpbnMiOlsiYXBleGNoYXJ0cy5jb20iLCIxMjcuMC4wLjEiLCJsb2NhbGhvc3QiXSwic2lnIjoieVBmb1VCc0Z3TU9ZdUEyaEZkR0I2Y1FtZ0JITUtXcVdJSjB2NVRESXRZbFR3eDJMUmh6R2x0RUc3VXJ4X0s3b25ZMWRZb2Z2VGItN01ydFYyNDVyOWcifQ==');
    for (var p = 1; p <= 12; p++) {
          var id = 'P-' + (p < 10 ? '0' + p : p)
          this.patientSeries.push({
            name: 'Heart rate',
            patient: id,
            data: this.heartRate(p * 7, 68 + (p % 5) * 4, p === 7 ? 12 : 0),
          })
        }
  }

  ngOnDestroy() {
    // no cleanup needed
  }
}